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The Relationship between Verniks Caseosa with C-Reaktif Protein (CRP) Levels and Premature Infant Wellness
Premature infants are still the leading cause of infant mortality in Indonesia. This is because
premature babies are a risk of infections, and other congenital complications. Premature babies tend to have
less vernix caseosa due to vernix caseosa production as well as surfactant production, i.e. at 21 weeks of
gestation and the older the gestational age the more vernix caseosa is most produced. The purpose of this
study was to determine the relationship between vernix caseosa and increased C-Reactive Protein (CRP)
levels toward well-being in premature infants. Using terminology design not the type of research is
analytical using a perspective cohort design. The research subjects treated in the NICU room at Putri
Surabaya Hospital in the period January to November 2021 were preterm infants between 0 and 1 month
of age, and premature infants with few vernix caseosa. Inclusion criteria were premature infants 0-1 months
of age, gestational age less than 38 weeks, birth weight 1500-2500 grams, a preterm newborn with vernix
caseosa, and little or without vernix caseosa. While the exclusion criteria were preterm newborns with
congenital complications and abnormalities. The data were analyzed using chi-square test and Pearson
correlation bimodal analysis. The results showed a relationship between vernix caseosa and CRP levels in
premature infants = 0.014, and vernix caseosa and wellness conditions in premature infants = 0.030, but no
relationship between CRP levels and premature wellness. children = 0.222. The conclusion is that the more
Vernix Caseosa in premature babies, the lower the CRP levels and the condition in which premature babies
become more agile.
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